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Our groups research centers aroung the concept of modularity in systems biology. Here are some relevant papers on modularity.

References

  1. Abdul Salam Jarrah, Reinhard Laubenbacher, Alan Veliz-Cuba. The Dynamics of Conjunctive and Disjunctive Boolean Network Models.Bulletin Of Mathematical Biology. 2010-8. 10.1007/s11538-010-9501-z
  2. John J Tyson, Katherine C Chen, Bela Novak. Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.Current Opinion In Cell Biology. 2003-4. 10.1016/s0955-0674(03)00017-6
  3. M. Girvan, M. E. J. Newman. Community structure in social and biological networks.Proceedings Of The National Academy Of Sciences. 2002-6-11. 10.1073/pnas.122653799
  4. Alexander P. Clark, Mukti Chowkwale, Alexander Paap, Stephen Dang, et al.. Logic-based modeling of biological networks with Netflux.Plos Computational Biology. 2025-4-4. 10.1371/journal.pcbi.1012864
  5. Leah V. Schaffer, Trey Ideker. Mapping the multiscale structure of biological systems.Cell Systems. 2021-6. 10.1016/j.cels.2021.05.012
  6. Herbert A. Simon. The Architecture of Complexity.Facets Of Systems Science. 1991. 10.1007/978-1-4899-0718-9_31
  7. Daniel Plaugher, David Murrugarra. Cancer mutationscape: revealing the link between modular restructuring and intervention efficacy among mutations.Npj Systems Biology And Applications. 2024-7-13. 10.1038/s41540-024-00398-6
  8. Dávid Deritei, William C. Aird, Mária Ercsey-Ravasz, Erzsébet Ravasz Regan. Principles of dynamical modularity in biological regulatory networks.Scientific Reports. 2016-3-16. 10.1038/srep21957
  9. Dávid Deritei, Jordan Rozum, Erzsébet Ravasz Regan, Réka Albert. A feedback loop of conditionally stable circuits drives the cell cycle from checkpoint to checkpoint.Scientific Reports. 2019-11-11. 10.1038/s41598-019-52725-1